The global anti-ageing market was valued at $58.5 billion by the close of 2020. This surprising figure shows how people are curious for a remedy that will slow down the ageing process, or better still, reverse ageing effects. For this reason, scientists have been busy trying to find the best natural solution for ageing in humans.
The solution lies in finding out the elements that decline as we age, and one of the most essential in these has been NAD+. This compound has been incorporated in the increasing number of anti-ageing supplements to improve longevity and keep the human body younger.
NAD+ supplements have increased in demand, considering they fight ageing at a cellular level and offer significant anti-ageing benefits throughout the body, potentially transforming lives. Scientists study the effects of NAD levels on other species to learn more about the possibilities for humans.
In this article we will delve deeper into the field of anti-ageing study and research development in this area.
What does NAD stand for & what is it?
NAD stands for Nicotinamide Adenine Dinucleotide. NAD is a coenzyme that naturally exists in the body. The coenzyme serves two core functions: transforming nutrients into energy and playing an integral part in the metabolic processes in regulating other cellular processes.
Do NAD supplements work?
NAD+ supplements have poor bioavailability; they do not affect when introduced into the body. However, NAD has intermediates, which transform into NAD+ through enzymatic reactions.
Various studies show that supplementing with nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) increases NAD levels and extends the lifespan of mice, yeast and worms. Other studies show that boosting NAD (nicotinamide adenine dinucleotide) can improve cardiovascular function, glucose metabolism and muscle generation in animals.
In human beings, research shows that cells absorb nicotinamide riboside, NR, directly from the blood converts it to NMN and then to NAD.
What are the benefits of taking NAD supplements?
NAD supplements can boost the production of NAD enzymes in the body. Studies show that NAD can treat various diseases and illnesses in the entire body.
Since it produces high energy levels, NAD can eliminate chronic fatigue syndrome, manage high cholesterol and improve athletic performance, among others. Also, NAD serves as a fuel to boost the brain and keep it functioning well; thus, more potent brain cells lead to more robust performance.
Can NAD Reverse Ageing?
NAD plays a significant role in the anti-ageing process. NAD goes into a cell’s mitochondria and increases the length of telomeres, the protective caps at the end of the chromosome that become shorter as the body ages.
This coenzyme increases the activities of the SIRT1 and PARP1 proteins that influence the repair of DNA damage and can slow the rate of ageing.
It has been proven that only a percentage of ageing can be attributed to our genes. Genetically some of the ageing process is determined for a person but a large percentage is down to life style, diet, exercise activity and our surrounding environment.
For example certain regions across the globe share similarities in their ageing populations. A ‘Blue Zone’ region is one which has a population of people ageing healthily and with a lack of chronic illness compared to other places in the world.
Is Vitamin B3 the same as NAD?
Vitamin B3 is a precursor to the coenzyme nicotinamide adenine dinucleotide (NAD+). The dietary B3 comprises nicotinamide, nicotinic acid and nicotinamide riboside. Effective salvaging of nicotinic acid and nicotinamide (vitamin B3) generates the bulk of intracellular NAD.
Nicotinamide Riboside (NR) is the only vitamin B3 from which NAD is generated in vitamin B1, B2 and B6 independently. Although NR is a minor component of vitamin B3, the salvage pathway using NR for the production of NAD is expressed in most eukaryotes.
Which NAD supplement is best?
NAD supplements are increasingly becoming famous as anti-ageing supplements. The more NAD present in your body, the more cells you will have to work with, resulting in a better cell function. The best NAD supplement is Tru Niagen.
Other supplements are Life Extension NAD+ Cell Regenerator, HPN Supplements NAD+3 NAD+ Booster, Alive By Science, Quicksilver Scientific Liposomal NAD+ Gold, Elysium, Liftmode NMN, RiboGEN and Toniq NMN, among others.
How can I boost my NAD levels naturally?
Though you can take supplements to boost NAD levels, a more efficient manner to keep NAD at its optimal level is to make relevant lifestyle changes.
Incorporating these changes into your lifestyle can ensure NAD stays robust to maintain a healthy metabolism and high levels of energy naturally.
Exercise regularly in one of the natural ways to keep your NAD level high and boost your overall health. It increases DNA rebuilding proteins; keep you strong at a healthy weight.
Fasting & Ketosis Diets
Fasting triggers body shock, thus boosting your natural supply of NAD. Ketosis diets aid to lose significant weight and enhance natural levels of NAD.
Consuming raw foods containing vitamin B1 such as avocados, peanuts, steamed fish and cow’s milk can increase levels of NAD. Add less-processed whole grains and fermented food and drinks such as kombucha to your diet to maintain higher amounts of B vitamins.
One group of organisms is particularly helpful in boosting NAD levels in the human body and these are mushrooms. These fungi are available in store, or out in nature in all different forms and types. Evidence shows the efficacy of mushroom consumption to naturally increase NAD levels internally.
Seeking the Heat
Spending time in natural and artificial heat such as saunas, hot tubs, and heated pools increases your heart rate. Hence requiring more energy from your body to keep cool; thus, triggering increased production of NAD to supply the needed energy.
Can you buy NAD+ in Ireland?
Yes. You can buy NAD in Ireland via online retail stores or selected health stores.
How much NAD should I take daily?
The daily NAD dosage depends on your health conditions and the effects you are anticipating out of it. Typically, the prescribed dosage ranges from 5 milligrams to 10 milligrams per day.
The average dosage ranges from 250 to 750mg in IV treatment infusions, with a safe range not exceeding 1500mg.
How long does NAD take to work?
The effects of NAD are noticeable almost instantly in most cases. When using a dietary plan with vitamin-rich foods to boost dopamine and produce NAD in the brain, you will need about 6 to 10 days of infusion to experience its effects.
A first IV therapy of NAD can give you results that will last for 4-14 days, depending on your health goals and conditions.
What are the side effects of NAD?
NAD has no adverse effects or reactions. However, during an active administration, some people may feel stomach discomfort, nausea, brain fog, tenderness and redness on the injection site, etc.
Are NAD injections safe?
NAD injections are safe and effective due to naturally occurring NAD in the body.
Does it interact with medications?
NAD has no known interactions with other drugs.
Does it raise blood pressure?
NAD can raise your blood pressure levels by making your blood vessels thicken, stiffen and become less flexible, thus making your heart work harder.
Are NMN and NAD the same?
NMN is a precursor to NAD; it changes to NAD after a series of chemical transformations. NAD is a coenzyme, and its levels naturally fall with age. NMN can only enter the cells after chemically transforming to NR, a highly efficient precursor to NAD, ultimately transforming to NAD.
Is it better to take one over the other?
It is better to take NMN, a direct precursor to NAD.
Are NAD supplements worth it?
NAD supplements are worth it since they contribute to general biological metabolisms in the body. The supplements boost NAD levels, which contribute to managing healthy sleep cycles, help cells repair damaged DNA and protect cells from stress.